Endocrine Abstracts

Graves’ disease (GD) is an autoimmune disease caused by autoantibodies binding to and activating the thyroid-stimulating hormone receptor (TSHR). Chronic stimulation of the TSHR results in a hyperactive thyroid gland and hyperthyroidism. The purpose of this study was to determine the association between Rho-kinase (ROCK1 and ROCK2) gene polymorphisms and GD in a Turkish population. A total of 142 patients with HT and 163 healthy control subjects were in...

Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid due to the presence of circulating anti-thyroid-stimulating-hormone receptor stimulating autoantibodies that lead to hyperthyroidism. Involvement of the genetic variants of RHO genes in GD has not been examined yet. Therefore, the aim of this study was to investigate possible associations between RHO gene polymorphisms and GD in a Turkish population. A total of 128 patients with GD and ...